Mac Pro systems tested with an attached Pro Display XDR. Testing conducted by Apple in August 2020 using 2.5GHz 28-core Intel Xeon W-based Mac Pro systems with 384GB of RAM and dual AMD Radeon Pro Vega II graphics with Infinity Fabric Link and 32GB of HBM2 each, configured with 4TB SSD as well as 2.4GHz 8-core Intel Core i9-based 16-inch MacBook Pro systems with 64GB of RAM and Radeon Pro 5600M graphics with 8GB of HBM2, configured with 8TB SSD.Performance will vary based on system configuration, media type, and other factors. Prerelease Final Cut Pro 10.4.9 with prerelease plugins from RED Apple Workflow Installer v16, and Final Cut Pro 10.4.8 with plugins from RED Apple Workflow Installer v15 tested on macOS Catalina, using an 11-second project with REDCODE® RAW 4:1 video, at 8192x4320 resolution and 23.98 frames per second, transcoded to Apple ProRes 422. ![]()
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![]() Gives more control over how Swinsian changes the audio device settings to match the current track.Allows using membership of other smart playlists as a rule in smart playlists.If youre asked, 'Do you want to allow this app to make changes to your device,' click Yes. ![]()
![]() Parents simply need to make a list of all the sight words their child needs to learn. Don’t forget to say each word when the card is flipped.Ĭhildren can go on a sight word scavenger hunt anywhere. Players take turns turning over two cards the player with the most matches is the winner. Shuffle all the cards and lay them face down. Parents and children can make two cards of each sight word. Whether parents dub this game ‘Sight Word Match’ or ‘Sight Word Memory’ doesn’t really matter the game is played the same regardless of the name. The player with the most matches is the winner. The object of the game is to get four cards of each word. This means that the rest of the cards in the deck are allocated to the ‘fish pond.’ Players take turns asking for cards. Play Sight Word Go Fish per the rules of the standard game. The number of cards that each player receives is dependent on the number of players, pass out seven cards (for just two players) or about five cards for three or more players. Decorate the backs to create a unique deck. Parents will need to make four cards of each sight word. Ready to have fun and learn? Here are games to play at home: Sight Word Go Fish Schedule sight word adventures throughout the weekend and encourage children to learn all the words on their list. What is the best app that helps with reading books that include sight words? What are the best games that parents can play? Here are some options:Ĭhildren learn through play, and sight words are easy to incorporate into fun activities and even family games. Parents can use games and apps to help children master their lists. Reviewing sight words doesn’t have to be yet another assignment, though. ![]() Sight word mastery aids in reading fluency, and practicing sight words at home is essential to help children gain mastery. These words are divided into lists across several grades, and young readers will become accustomed to memorizing sight words as part of their reading curriculum. The Dolch List of sight words includes 220 common words that children are eventually expected to know by sight. SpaceX came in third with a rating of "acceptable" in both management and technical arenas. "Technically, the design appears to be sound, but this design can only come to fruition as a result of a very significant amount of development work that must proceed precisely according to Blue Origin's plan, including occurring on what appears to be an aggressive timeline," according to the source selection statement. Concerns listed were the complexity of the descent stage's propulsion system, Blue's lack of flight experience and "multiple relatively low technology readiness level systems that will be challenging to manufacture, integrate, and test." but would need to be developed at a speed that does not align with historical experience."īlue Origin received a "very good" management rating and an "acceptable" technical rating. Concerns included a complex power and propulsion system that "relies upon technologies that are at relatively low maturity levels or that have yet to be developed. NASA's source selection statement, listing the strengths and weaknesses of each company's proposal, shows Dynetics with "very good" management and technical ratings, the highest of all three. After that, NASA plans to award follow-on contracts to at least two teams. During that period, NASA will evaluate the proposals in detail and determine what sort of tests will be needed to certify them for human spaceflight. ![]() The base period of the contracts, totaling $967 million, runs 10 months through next February. With large habitable and storage volume, Starship is capable of delivering significant amounts of cargo for research and to support robust operations on the lunar surface to enable a sustainable Moon base- SpaceX April 30, 2020 Much larger than its competitors, the Starship would not need to dock with Gateway to pick up supplies or other equipment. SpaceX was awarded about $135 million for a proposal built around the company's "lunar-optimized" Starship rocket. It, too, would be capable of using the Gateway station. Made up of three stages, the Blue Origin lander, capable of docking with the Gateway station, would be launched on the company's New Glenn rocket or a United Launch Alliance Vulcan booster.ĭynetics, partnering with Sierra Nevada, won a reported $253 million contract and would launch a two-stage, re-fuelable lander atop a Vulcan. But the initial 2024 landing does not require Gateway, which may or may not be finished by then.īlue Origin, a company owned by Amazon founder Jeff Bezos, was reportedly awarded $579 million to develop a lander with partners Lockheed Martin, Northrop Grumman and Draper Labs. We want to make sure that this program, the Artemis program, goes on for generations to come." A lunar lander design from an industry team led by Dynetics.Ī key to sustainability, Bridenstine said, is a small space station called Gateway that NASA plans to build in a high lunar orbit to serve as a staging base for landing at different sites around the moon. "The challenge with Apollo is that it ended. "We need to be able to go and be able to go again and again and again," he said. "This is the first time since the Apollo era that NASA has direct funding for a human landing system, and now we have companies on contract to do the work for the Artemis program." An artist's impression of Blue Origin's lunar lander on the surface of the moon.Īfter two unpiloted test flights of Boeing's gargantuan Space Launch System (SLS) heavy-lift booster in 2021 and the 2022-23 timeframe, NASA plans to launch the first Artemis crew to the moon aboard a Lockheed Martin Orion capsule atop an SLS booster by the end of 2024. "With these contract awards, America is moving forward with the final step needed to land astronauts on the moon by 2024, including the incredible moment when we will see the first woman set foot on the lunar surface," NASA Administrator Jim Bridenstine said in a statement. ![]() SpaceX and teams led by Dynetics and Blue Origin won NASA contracts Thursday totaling nearly $1 billion to develop lunar landers that could carry astronauts back to the moon as early as 2024 and support sustained, long-term operations by 2028 under the space agency's Artemis program. "Apollo on steroids": NASA's mission to get the first woman and next man to the moon by 2024 04:49 ![]() ![]() ![]() Shin Megami Tensei: Persona 4 Persona 4 Arena Persona 4 Golden Chie Satonaka Yukiko Amagi, Playstation, electronics, boy png 3000x3000px 906.78KB.Shin Megami Tensei: Persona 3 Persona 4 Arena Shin Megami Tensei: Persona 4 Persona 4 Golden, pepsi, video Game, fictional Character png 698x1200px 274.63KB.BlazBlue: Cross Tag Battle Persona 4 Arena Shin Megami Tensei: Persona 4 Yu Narukami BlazBlue: Continuum Shift, playStation 4, video Game png 874x1160px 514.97KB.Shin Megami Tensei: Persona 4 Persona 4 Golden Persona 4: Dancing All Night Rise Kujikawa Persona 4 Arena Ultimax, read, black Hair, hand png 955x758px 477.3KB.Shin Megami Tensei: Persona 4 Shin Megami Tensei: Persona 3 Persona 4: Dancing All Night Persona 4 Arena Persona 4 Golden, cartoon, fictional Character png 800x744px 449.35KB.Persona 4: Dancing All Night Shin Megami Tensei: Persona 4 Yu Narukami Persona 4 Arena Persona 3: Dancing Moon Night, yu, video Game, shoe png 761x1415px 115.19KB.Shin Megami Tensei: Persona 4 Persona 4 Golden Shin Megami Tensei: Persona 3 Persona 4: Dancing All Night Persona 4 Arena, Wall Desing, video Game, fictional Character png 1314x1200px 6.02MB.Shin Megami Tensei: Persona 4 Persona 4 Arena Ultimax Chie Satonaka Yu Narukami, Chie Satonaka, video Game, kung Fu png 600x1238px 284.42KB.Persona 4: Dancing All Night Shin Megami Tensei: Persona 4 Persona 4 Golden Rise Kujikawa Shin Megami Tensei: Persona 3, dancing beauty, video Game, fictional Character png 771x1152px 122.87KB.BlazBlue: Cross Tag Battle Yukiko Amagi Persona 4 Arena Shin Megami Tensei: Persona 4 Chie Satonaka, black Hair, video Game png 600x1212px 510.4KB.Shin Megami Tensei: Persona 4 Persona 4 Arena Chie Satonaka Yukiko Amagi Persona 4: Dancing All Night, black Hair, video Game png 1024x1024px 372.8KB.Shin Megami Tensei: Persona 4 Yukiko Amagi Persona 5 Drawing, Anime fight, sticker, fictional Character png 700x391px 169.65KB.Shin Megami Tensei: Persona 4 Naoto Shirogane Persona 4 Arena Ultimax Persona 4: Dancing All Night, detective, video Game, detective png 2437x2048px 88.37KB.Shin Megami Tensei: Persona 4 Persona 4 Golden Persona 5 Shin Megami Tensei: Persona 3 Rise Kujikawa, black Hair, video Game png 1024x1801px 867.87KB.Shin Megami Tensei: Persona 4 Persona 4 Arena Ultimax Rise Kujikawa Persona 4: Dancing All Night, black Hair, fictional Character png 478x1200px 323.97KB.Shin Megami Tensei: Persona 4 Persona 4 Arena Ultimax Persona 4 Golden Persona 5, Persona 4, video Game, fictional Character png 577x1495px 425.2KB.Persona 4 Arena Ultimax Shin Megami Tensei: Persona 4 Shin Megami Tensei: Persona 3 Chie Satonaka, pantheon, video Game, fictional Character png 673x1953px 510.66KB.Shin Megami Tensei: Persona 4 Persona 4 Arena Persona 4 Golden Shin Megami Tensei: Persona 3 Yukiko Amagi, Persona 4 Arena, black Hair, video Game png 500x593px 229.75KB.Non-commercial use, DMCA Contact Us Relevant png images ![]() Single-cell RNA-sequencing identifies discrete populations of cells undergoing the osteoblast-to-osteocyte transition, and dramatic defects in this normal process in the absence of Sp7. Amongst osteocyte-specific Sp7 target genes, we identify osteocrin as a secreted factor that promotes osteocyte dendrite formation/maintenance in vitro and in vivo. Osteocyte-specific Sp7 target genes have DNA-binding sites distinct from those in osteoblasts and are highly enriched in genes expressed in neurons, highlighting shared molecular links between intercellular communication networks in brain and bone. Unbiased profiling of Sp7 target genes and binding sites in osteocytes reveals a stage-specific role for this transcription factor during osteocytogenesis. In this work, we delete Sp7 in mature osteoblasts and osteocytes and observe a dramatic skeletal phenotype including cortical porosity, increased osteocyte apoptosis, and severe defects in osteocyte dendrites. However, the function of Sp7 in osteocyte maturation remains unknown. Common human SP7-associated variants are linked to bone mineral density variation and fracture risk 12, 13, and rare SP7 mutations cause recessive forms of osteogenesis imperfecta 14, 15. Osterix/Sp7 (encoded by the Sp7 gene) is a zinc finger-containing transcription factor essential for osteoblast differentiation and bone formation downstream of Runx2 11. The goal of this study was to define key gene regulatory circuits that drive osteocyte differentiation and dendrite formation. Lineage-specifying transcription factors have been identified for other key cell types in bone 10 however, lineage-defining transcription factors that coordinate genetic programs associated with osteocyte maturation remain unknown. Recent estimates suggest that the osteocyte connectivity network in human bone exhibits the same order of complexity as the network of connections between neurons in the brain 9. Defects in the osteocyte dendrite network may cause skeletal fragility in the setting of aging and glucocorticoid treatment 7, 8. The osteocyte dendritic network confers mechano-sensitivity to these cells and allows for extensive communication among osteocytes and adjacent cells on bone surfaces 6. Furthermore, osteocytes have a unique morphology as they bear multiple long, neuron-like dendritic processes projecting through the lacunar canalicular system in bone 5. These cells translate external cues, such as hormonal variations and mechanical stresses, into changes in bone remodeling by secreting paracrine-acting factors that regulate osteoblast and osteoclast activity 4. Recently, emerging evidence has highlighted key roles for osteocytes in bone remodeling 3. Although the roles of osteoblasts and osteoclasts in bone formation and resorption have been well studied 1, 2, those of osteocytes, the most abundant cell type in bone, had been overlooked due to technological limitations and the cells’ relatively inaccessible location within the mineralized bone matrix. The major cell types that govern bone homeostasis are osteoblasts, osteoclasts, and osteocytes. These findings reveal a role for Sp7 and its target gene Osteocrin in osteocytogenesis, revealing that pathways that control osteocyte development influence human bone diseases. Sp7-dependent genes that mark osteocytes are enriched in neurons, highlighting shared features between osteocytic and neuronal connectivity. Moreover, humans with a SP7 R316C mutation show defective osteocyte morphology. Sp7-dependent osteocyte gene networks are associated with human skeletal diseases. Single-cell RNA-sequencing demonstrates defects in osteocyte maturation in the absence of Sp7. Osteocrin is a Sp7 target gene that promotes osteocyte dendrite formation and rescues defects in Sp7-deficient mice. Profiling of Sp7 target genes and binding sites reveals unexpected repurposing of this transcription factor to drive dendrite formation. Here we show that deletion of Sp7 in osteoblasts and osteocytes causes defects in osteocyte dendrites. The circuitry that drives dendrite formation during “osteocytogenesis” is poorly understood. Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing osteocytes. Nature Communications volume 12, Article number: 6271 ( 2021) Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin ![]() ![]() Pay-what-you-want is allowed as long as '0' is an option. If you link to an external website to share your brew, it can’t be hidden behind a cumbersome interface or series of pages. Even content in the public domain or art you made must be cited, since the moderators can't know the source in advance.Ĭontent you post or comment must be free and easy to access. Don't cite a host (like Pinterest) or a game (like Elder Scrolls). It must include the name of the original creator, the copyright holder (e.g., SEGA for Sonic), or the AI used. The citation must appear in any image, link, or document you post (not in a comment or title). Look at r/UnearthedArcana/wiki/art to learn why and how. See our wiki page for details on what each flair type covers, how to choose a flair, and why we have this rule.Īny content (text, images, etc.) must be cited. When you submit a post, apply a flair to it to categorize what type of homebrew you’ve made. See r/UnearthedArcana/wiki/titles for details on what makes a title bad or good.Īpply the Appropriate Flair to Your Submission. the name of the subclass you’re submitting).ĭon’t use distracting formatting (all-caps, ascii art, custom “tags”, etc.), and avoid overly long or redundant titles.ĭon't advertise other content (Kickstarters, Patreon, Giveaways) in your title. Give your post a title that clearly communicates what's inside it. Users need to be able to easily browse and search for content. Certain content can be posted with only the earlier stages completed as long as it's usable (i.e., at least levels 1-5 for classes, levels 1-13 for subclasses). Imagery alone is not content outside of a resource (one of our flair types).įor help with not-yet-complete content, use The Arcana Forge post at the top of the subreddit or the official Discord. It need not be perfect or balanced but it must be complete enough to be used as-is, and not AI generated. Post Only Complete/Usable 5e and One D&D Compatible Content. Repeat or extreme offenders will be banned. Please report any violations to the moderation team. Posts/comments that promote rape, real-world hate/violence, or other inappropriate themes will be removed. Don’t give rude, belittling feedback, and don't use harmful words. This can only lead to a better community, and ultimately, better brews. Be constructive in how you give and take feedback. We want this to be the place where a DM can go just before playing and find something that will be useful. R/UnearthedArcana aims to be a catalogue of homebrew rules for the fifth edition of Dungeons & Dragons ( D&D 5e) and the forthcoming One D&D, including weapons, monsters, races, subclasses & classes, adventures, etc. Fun and smart additions to the game, the friendly Discord of Many Things, and thousands of past submissions to search. A subreddit for D&D 5e and One D&D homebrew. But most of them are based on traits found in "Additional Traits," "Extended Traits," "L-Traits," and/or the base version of "Pawns Are Capable!" Some of the traits added by this mod are original. You should be able to add "Consolidated Traits" to an existing saved game without trouble, but removing the mod from a game in progress might cause problems if any pawns in the world have any of the mod's traits, which is of course very likely. Combining a larger pool of traits with a larger set of traits per pawn can add some very interesting and uniquely individual personalities to your game. I'd recommend using my "More Trait Slots" mod. However, if you're using more than one mod that adds traits, you might end up seeing pawns with traits that don't really work well together, since the game won't have any way of knowing that trait X from mod Y duplicates or just isn't compatible with trait A from mod B. Even if those mods add similar traits, there shouldn't be any conflicts, as the traits are unlikely to have the same defNames. "Consolidated Traits" should be compatible with most other mods. "Weak Constitution"/"Strong Constitution": These traits affect a pawn's resistance to pathogens and diseases. "Unstoppable"/"Ironman"/"Low Pain Tolerance": These traits affect a pawn's pain tolerance. "Uncouth"/"Diplomat"/"Master Diplomat": These traits affect the success of a pawn's diplomatic efforts. "Sucker"/"Haggler"/"Master Trader": These traits affect prices when a pawn is trading. "Savant": Pawns with this trait are creative geniuses, but terribly slow workers. "Rockhound": Pawns with this trait excel at mining and stonecutting, but are a bit slow at other tasks. "Poor Medic"/"Skilled Medic"/"Master Medic": These traits provide penalties or buffs to medical skills. "Perfectionist": Pawns with this trait try to make sure their work is done right, no matter how long it takes. "Nyctophobe"/"Nyctophile": These traits make pawns either more or less afraid of the dark than usual. "Nibbler": Pawns with this trait eat very slowly, picking at their food. "Neat Freak": Pawns with this trait appreciate the importance of a dirt-free environment. "Inventor": Pawns with this trait are great researchers, but tend to be easily distracted. "Inept": This trait is the counterpoint to "Coordinated." "Heat Lover": This is the counterpoint to "Cold Lover." "Gourmet": Pawns with this trait prepare excellent food, but take their time in doing so. "Glutton": Pawns with this trait eat very quickly. "Dunce": Pawns with this trait will learn at a slower rate. "Deep Sleeper": Pawns with this trait won't be disturbed by others while sleeping. "Decent Learner"/"Slow Learner": Join Fast learner to broaden the speed of pawn learning. "Deadshot": This provides a boost to both shooting speed and accuracy. "Cranial Nerve Palsy"/"Eagle-Eyed": These traits affect primarily a pawn's shooting accuracy. "Coordinated": This one provides a slight boost to global work speed and to most skilled labor. "Cold Lover": Pawns with this trait will complain less when it's cold, but will whine more when it's hot. "Claustrophobic": Pawns who don't like confined spaces make poor miners. "Butcher": Pawns with this trait are much faster when butchering animal corpses. "Builder": Pawns with this trait are good at constructing things, at least if they have instructions. "Animal Lover": Pawns with this trait, as you'd expect, are especially good at dealing with animals. "Animal Hater": Some pawns just aren't "animal people." "Aesthete": Pawns with this trait love beautiful things, and care a lot about the beauty of their environment. "Consolidated Traits" adds 45 traits to the game, almost doubling the number of traits available for pawns. And I'm reasonably certain it's bug-free. *Shrug* What can I say? This one, at least, has the traits I like, all the traits I like, and nothing but the traits I like. releasing yet another trait collection mod. So I decided to deal with the problem by. ![]() ![]() When I started looking for a mod to add more traits to the game, I quickly realized three things about the various trait collection mods that are available: they all have some traits I really like, but also some I dislike, and none of them had all the traits I wanted they don't necessarily work very well together due to conceptual overlaps or conflicts and some of them are buggy in one way or another. ![]() ![]() Jack Lingo Realtor - Rehoboth Beach, Lewes and Millsboro Delaware - Real. All such actions shall be entirely at the owner’s risk. Welcome to Shorts Marine - We are Delmarvas Leading Boat & Motor Dealer Since. Police say the incident occurred on Delaware Ave near Lingo. Lingo Marine Inc was started by Dale and. The Millsboro Police Department is asking for the public’s help in locating a man who reportedly chased a child in a yard today. Further, Lingo Marine shall not be held liable for damages that may arise during the hauling out of the water or the launching into the water of the owner’s watercraft.ģ. See reviews, photos, directions, phone numbers and more for the best Boat Dealers in Millsboro, DE. Lingo Marine shall not be held liable for any damages to any watercraft, its attachments or accessories, and/or any trailer upon which it may be presented for storage, by virtue of this agreement, for any reason, including but not limited to material loss or delay of service, caused by any act of God or by riot, fire, vandalism, theft, or for any other reason, or from any damages resulting from a defect in the boat or its trailer, as delivered to Lingo Marine.Ģ. The business is a result of their interest in boating. Call (302) 934-9877 to book an appointment or to hear more about the services of Lingo Marine INC. Lingo Marine Inc was started by Dale and Gerry Lingo in 1961. Lingo Marine INC located at Delaware Av in Millsboro, DE services vehicles for Boat Supplies. Motor Vehicle Dealers Retail Lingo Marines Social Media. However, as preparations for seasonal use require sufficient advance notice to accommodate all clients, in a fair and orderly manner, Lingo Marine requires that you Contact Us a minimum 0f three (3) weeks in advance 0f your desired launch date.ġ. 121 Delaware Ave, Millsboro, Delaware, 19966, United States. ![]() See reviews, photos, directions, phone numbers and more for Dannys Marine locations in Millsboro, DE. Lingo Marine will always strive to provide requested services in a timely manner. Find 219 listings related to Dannys Marine in Millsboro on YP.com. Our Storage Area Tends To Fill Early… and Quickly…So Please Register Early! He was founder, and owner of Lingo Marine in 1961, and the Lingo Bus Service. Boat DealersMarine Equipment & SuppliesMarinas From Business: Lingo Marine Inc was started by Dale and Gerry Lingo in 1961. Get Lingo Marine Inc reviews, rating, hours, phone number, directions and more. Get Lingo Marine Inc can be contacted at (302) 934-9877. Includes Larger Fiberglass Boats Which May Require Blocking Lingo Marine Inc at 121 Delaware Ave, Millsboro, DE 19966.Call (302) 629-9690 for more information. Mercury marine provides marine engines, guages & control, propellers, inflatable boats, and parts & accessories to keep your water equipment running smoothly without a hitch. The town of Woodland hosts an annual festival honoring the history of the ferry. They started the business working together. Located between Middleford and Woodland Roads, southwest of Seaford. From Business: Lingo Marine Inc was started by Dale and Gerry Lingo in 1961. Today, it transports up to 3 vehicles at a time across the scenic Nanticoke River. Established in 1793 by the Cannon family, the ferry once served as a major river crossing and trading center for locals and travelers. The small cable run ferry, crossing the Nanticoke River, is one of the last remaining ferries of its kind on the East Coast. ![]() The song is a woozy, faded, screwed-down odyssey, replete with helium warble and dewy third eye-and it’s actually one of the album’s most propulsive tracks. It’s also the most overtly political statement Frank makes across the entire record. Even now, four years after the Florida teen was shot and killed with Skittles in his pocket, the line jolts. In the song’s video, Frank holds up a framed photo of the 17-year-old martyr, the boy’s sad eyes tucked inside a hoodie. “RIP Trayvon, that nigga look just like me,” he sings on “ Nikes,” the opening track from Blonde, his wary exhale of a new album. How his voice was allergic to nonsense, how it could shatter a heart into dust. How he allowed us to escape within his carefully drawn characters while never letting us off the hook. There was a yearning for his perspective-how he could soothe without losing sight of what’s important. The stoic empathy he beamed throughout Channel Orange was missed. Though he posted several elegant messages online, reacting to horrors in Ferguson and Orlando, his relative silence only grew louder as tensions outside continued to rise. ![]() How dare you just be excellent?” The Rock quote is from a 2012 profile of the reclusive D’Angelo, who felt compelled to release his first album in 14 years following the shooting of Michael Brown the moment spurred him on.įaced with a hellish loop of police brutality, other musical leaders like Kendrick Lamar and Beyoncé came forth with brilliant righteousness as well. “You represent the race, and you have responsibilities that go beyond your art. “Black stardom is rough,” Chris Rock once said. There are precedents for this sort of thing, for disappearances, for the self-implosion of black genius. He could be the dynamic human of the future, exploding age-old binaries with an eloquent note, melting racial divisions with a devastating turn of phrase or quick flit to falsetto. Then he became the story-an avatar for all of our fluid modern ideals. At first, Frank Ocean was simply a great storyteller. |
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